In Vitro − In Vivo correlation IVIVC Equipment

In Vitro − In Vivo Correlation (IVIVC), as defined by the FDA, is a predictive mathematical model describing the relationship between the in vitro property of a dosage form and relevant in vivo response. The FDA has provided little to no guidance on IVIVC practices, but there is growing interest including an FDA draft guidance using IVIVC methods for a generic drug development.

A basic system is comprised of two more-realistic elements to give a more accurate representation of how a drug may behave in a specific type of patient’s respiratory system: the first is a more anatomically representative mouth and throat feature, and the second is a more representative breathing pattern.

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Other Products and Services from TSI Instruments Ltd

Particle Sizers

TSI provides aerosol sizing instruments that expand our understanding of aerosols and lead to breakthroughs in research and a wide range of industries. TSI manufactures particle sizing instrumentation and systems that span the particle size range from 1 nm to 20 micrometers. Our instruments are routinely used around the globe in a variety of applications, including air quality monitoring, aerosol research, engine emissions, exposure studies, and many more.

TSI’s particle sizers provide particle size ranges for a variety of applications, click below to discover how TSI can support your research and measurement needs.

Abbreviated Impactor Measurement (AIM) Equipment

The Abbreviated Impactor Measurement (AIM) Method implies using a shorter process to characterize aerodynamic size. It has been promoted as an alternative to the labor-intensive full resolution cascade impactor methodology for APSD (aerodynamic particle size distribution) testing.

Using an AIM methodology for early stage development has become increasingly popular as both OINDP device and drug companies look for ways to shorten drug development. This technology has traditionally been limited to early development signals indicating rough drug particle size, and this equipment is still intended to categorize the entire dosage for effective mass balance exercises.

Flow Meters, Flow Sensors & Flow Analyzers

For half a century, TSI has earned the reputation as a leader in designing and manufacturing flow measurement instrumentation. TSI mass flow meters, Certifier flow analyzers, and mass flow sensors for gases are used worldwide in laboratory and manufacturing settings, plus embedded applications. Our flow meters, flow analyzers, and embedded flow sensors are optimized for medical applications where accuracy and reliability are key requirements.

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TSI Instruments Ltd

Stirling Road, Cressex Business Park, High Wycombe, Buckinghamshire, HP12 3ST, United Kingdom

TSI Ltd serves a global market by investigating, identifying & solving measurement problems. As an industry leader in the design & production of precision measurement instruments, TSI partners with research institutions & customers around the world to set the standard for measurements relating to Respirator Fit Testing, aerosol science, air flow, indoor air quality, fluid dynamics and biohazard detection. With headquarters based in the U.S. & field offices throughout Europe & Asia, TSI has established a worldwide presence in the markets we serve.

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